Beneficial Effects of Low-Dose Benidipine in Acute Autoimmune Myocarditis-Suppressive Effects on Inflammatory Cytokines and Inducible Nitric Oxide Synthase-
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منابع مشابه
Aloe vera toxic effects: expression of inducible nitric oxide synthase (iNOS) in testis of Wistar rat
Objective(s): Nitric oxide (NO), a product of inducible nitric oxide synthase (iNOS), contributes in germ cell apoptosis. This study was aimed to evaluate the effects of Aloe vera gel (AVG) on male Wistar rat reproductive organ, serum NO level, and expression of iNOS gene in leydig cells. Materials and Methods:Adult male Wistar rats (n=36) were used for experiments in three groups. The experim...
متن کاملAre Controlled by Inducible Nitric Oxide Synthase Immunostimulatory Effects of Low-Dose Cyclophosphamide
Cyclophosphamide is a widely used chemotherapeutic drug that was recently applied as either an antiangiogenic/ antivasculogenic or an immunostimulatory agent in combination with cancer immunotherapies. It has been previously shown that cyclophosphamide augments the efficacy of antitumor immune responses by depleting CD4CD25 T regulatory cells and increasing both T-lymphocyte proliferation and T...
متن کاملImmunostimulatory effects of low-dose cyclophosphamide are controlled by inducible nitric oxide synthase.
Cyclophosphamide is a widely used chemotherapeutic drug that was recently applied as either an antiangiogenic/antivasculogenic or an immunostimulatory agent in combination with cancer immunotherapies. It has been previously shown that cyclophosphamide augments the efficacy of antitumor immune responses by depleting CD4+ CD25+ T regulatory cells and increasing both T-lymphocyte proliferation and...
متن کاملInducible nitric oxide synthase and inflammatory diseases.
Nitric oxide (NO) is a colorless gas at room temperature and one of the simplest molecules known, yet it has been implicated in a wide variety of regulatory mechanisms ranging from vasodilatation and blood pressure control to neurotransmission. It is also involved in nonspecific immunity and participates in the complex mechanism of tissue injury as a major mediator of inflammatory processes and...
متن کاملBeneficial effects of neuronal nitric oxide synthase in atherosclerosis.
Endothelial nitric oxide synthase (eNOS) is the only NOS isoform expressed in normal coronary arteries. However, all 3 NOS isoforms—eNOS, inducible NOS (iNOS), and neuronal NOS (nNOS)—are found in human atherosclerotic plaques.1 Precise studies of knockout mice have uncovered the role of eNOS and iNOS in atherogenesis (Figure). The eNOS isoform protects against atherosclerosis, because mice lac...
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ژورنال
عنوان ژورنال: Circulation Journal
سال: 2003
ISSN: 1346-9843,1347-4820
DOI: 10.1253/circj.67.545